Hypothyroidism A possible Risk Factor for Polycystic Ovary Syndrome among Jordanian Women

Abstract

Women with PCOS demonstrate hormonal disturbances and serum lipid derangements. The aim of this study is to evaluate the possible existence, or any risk of hypothyroidism on PCOS among Jordanian women. Some serum hormones were measured with determination of serum lipid alterations as parameters in patients with PCOS, hypothyroidism, and compared with clinically health controls. The higher LH level observed in both PCOS and hypothyroidism as compared to control group with no statistically significant difference between them, and this could be attributed to higher androgen levels that desensitize the hypothalamus to the progesterone negative feedback regulation mechanism, also increased serum PRL was observed in PCOS, and was significant difference with hypothyroidism and control group, and (PROG) showed no alteration between all groups, while both (FSH) and (E2) showed significant difference among all groups but their values were in normal ranges and only (25 out of 42, 59.52%) patients with PCOS had SCH when TSH level range from (< 6.5 µIU/ml and > 10 µIU/ml ) as a hidden endocrine disturbance that may increases the PCOS risks and contribute enhances of some other dangerous diseases. Although, in the case of serum lipid's profiles, higher concentration of (TG) was observed in both PCOS and hypothyroidism groups with statistically significant deference, and the higher level of (T. CHOL and LDL) was noted between PCOS and hypothyroidism groups with no statistically significant difference between them, while both of which had significant difference with control group and no significant difference noted in HDL level between all groups at (P< 0.05).